Research Associate (Preclinical & Translational Science)
Company: Atara Biotherapeutics
Posted on: December 8, 2018
We launched Atara Biotherapeutics in August 2012 to help patients with serious diseases and few therapeutic options. We're named after Atara Ciechanover who suffered from cancer before passing away. We are considered a leading off-the-shelf T-cell immunotherapy company (Nasdaq ATRA ) developing novel treatments for patients with cancer, autoimmune and viral diseases. Position Summary The Research Associate role is a best fit for a highly motivated and experienced bench scientist with specific interests and expertise in the conduct of cell-based assays in GLP/GCLP environment. This position directly supports key clinical correlative assays for our lead clinical programs and pivotal studies for Atara's lead product, tab-cel---, in the treatment of post-transplant lymphoproliferative disease. The Research Associate also supports ad hoc preclinical assay development when possible. This role has the opportunity to innovate and inform Atara's early development programs. Reports to Scientist, Preclinical & Translational Science Location Denver (Aurora - Fitzsimons Innovation campus) area, CO Primary Responsibilities Responsible for technical execution of established clinical correlative assays focused on functional T cell characterization. Assists in routine cell culture and conduct of in vitro assays under the supervision of translational scientist. Level of supervision will be commensurate with candidate experience. Maintains assay records, data, and documentation in a GCLP environment. Maintains lab equipment and consumable stocks. Contributes to early development of novel assays and ad hoc research competencies. Aids in the development of early cellular therapy assets. Ability to infrequently work during off-hours. Role model for Atara's Values of patients first, innovation teamwork, community and mindset. Travel Infrequent (up to 10% travel time) Physical Requirements Subject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is generally performed in an office or laboratory setting. Position Requirements 2-5 years relevant research experience in cancer biology with focus on cell therapy/immunotherapy with a bachelor's degree (master's degree is preferred). Proficiency in aseptic cell culture is a must and experience with immunoassay techniques is required. A functional understanding of T cell function, immunology, biochemical pathways, and mammalian cell culture processes is highly recommended. Experience with co-culture-based immunoassays and chromium release assays. Strong record keeping skills, including in a GLP/GCLP environment. Excellent problem-solving skills. Strong verbal and written communication skills, including summary distillation of complex experimental data and results. Expertise and rote familiarity with co-culture techniques, flow analysis, molecular biology skills, statistical data analysis. Track record for delivering high quality data and demonstrating competence in bench research is a must. More About Atara Now in our sixth year, we're proud of our team of 260 Atarians co-located by design in South San Francisco (corporate headquarters) and Southern California (R&D and manufacturing headquarters in the northwest Los Angeles area) with a newly-established European headquarters in Zug, Switzerland. Atara also has a R&D site in the Denver, Colorado area and an office in New York City. Our Southern California hub is anchored by a new 90,000 sq. ft., state-of-the-art Atara T-Cell Operations and Manufacturing (ATOM) facility in Thousand Oaks, California. One mission - "Transform the lives of patients with serious medical conditions through pioneering science, teamwork and expertise" - and a singular vision - "Cell therapy treatment for every patient, any time - provide inspiration and direction for all of us." The Company's off-the-shelf, allogeneic T-cells are bioengineered from donors with healthy immune function and allow for rapid delivery from inventory to patients without a requirement for pretreatment. Atara's T-cell immunotherapies are designed to precisely recognize and eliminate cancerous or diseased cells without affecting normal, healthy cells. Atara's most advanced T-cell immunotherapy in development, tabelecleucel, or tab-cel--- (formerly known as ATA129), is being developed for the treatment of patients with Epstein-Barr virus (EBV) associated post-transplant lymphoproliferative disorder (EBV PTLD) who have failed rituximab, as well as other EBV-associated hematologic and solid tumors, including nasopharyngeal carcinoma (NPC). Tab-cel--- is in Phase 3 clinical development for the treatment of EBV PTLD following an allogeneic hematopoietic cell transplant (MATCH study) or solid organ transplant (ALLELE study). Atara is also developing off-the-shelf, allogeneic ATA188 and autologous ATA190 T-cell immunotherapies using a complementary targeted antigen recognition technology for specific EBV antigens believed to be important for the potential treatment of multiple sclerosis (MS). A Phase 1 clinical study of autologous ATA190 in patients with progressive MS is ongoing. Atara is also advancing a Phase 1 clinical study of ATA188 in patients with progressive or relapsing-remitting MS across clinical sites in the United States and Australia. Atara's clinical pipeline also includes ATA520 targeting Wilms Tumor 1 (WT1) and ATA230 directed against cytomegalovirus (CMV). Working at Atara Biotherapeutics People at Atara are high integrity, roll-up-your-sleeves, get-it-done types who are keenly committed to putting patients first, advancing medical care and doing so with demonstrated urgency. At their core Atarians are people who work well with others and are "team-centric", have purposeful curiosity and can't wait to save patient lives. And similar to other biotech companies who have so many accomplished people, we expect humility (we are a "low hubris" sort of place), flexibility, respect, teamwork, good judgment and getting the most out of any dollar we spend. We also expect to enjoy the journey (and each other) as we move forward with a shared responsibility to teach and to learn from what we do and from our teammates. Atara is an equal opportunity employer and makes employment decisions on the basis of merit and other lawful factors. In accordance with applicable law, the Company prohibits discrimination based on race, color, religion, creed, sex, gender (including pregnancy, childbirth or medical condition related to pregnancy or childbirth), gender identity, expression or dysphoria, marital status, age, national origin or ancestry, physical or mental disability, medical condition, genetic information, veteran status, caregiver status, sexual orientation, transgender status or any other classification protected by federal, state or local laws or because of the individual's association with a member of a protected group or connection to an organization or group related to a protected group. We comply with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Atara Bio in the United States.
Keywords: Atara Biotherapeutics, Aurora , Research Associate (Preclinical & Translational Science), Other , Aurora, Colorado
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